SAGE KE Highlights From Science's Table of Contents
[2006] [2005] [2004] [2003] [2002] [2001]
30 June 2006
I Come Not to Bury SAGE KE But to Appraise It E. Strauss.
One of the site's creators tells a personal story of its rise and demise.
[Abstract] [Full Text]
Death-Bed Prophecy M. Leslie.
On the eve of its termination, SAGE KE takes a look at the future of research on aging.
[Abstract] [Full Text]
Targeting the Role of the Endosome in the Pathophysiology of Alzheimer's Disease: A Strategy for Treatment B. A. Tate and P. M. Mathews.
Alzheimer's disease-associated endosomal abnormalities might provide a route for drug-based interventions.
[Abstract] [Full Text]
Dementia with Cerebrovascular Disease C. B. Wright, J. P. G. Vonsattel, K. Bell, L. S. Honig.
A case study.
[Abstract] [Full Text]
WRN's Tenth Anniversary F. M. Hisama, V. A. Bohr, J. Oshima.
What have we learned about RecQ helicase function in a segmental progeroid syndrome and normal aging?
[Abstract] [Full Text]
The Unusual Genetics of Human Longevity G. De Benedictis and C. Franceschi.
Centenarians provide a unique opportunity for understanding "longevity genes."
[Abstract] [Full Text]
Aging On the Job J. Levine, J. Heet, B. Burlingame.
As the population ages, will the workforce decline along with it?
[Abstract] [Full Text]
The Role of Mitochondria in Conserved Mechanisms of Aging C. Scheckhuber and H. D. Osiewacz.
Report from the second "MiMage" symposium describes research on a variety of systems.
[Abstract] [Full Text]
Developing a Research Agenda in Biogerontology: Physiological Systems J. L. Carrington and F. L. Bellino.
Research supported by the National Institute on Aging aims to understand the biology of aging tissues.
[Abstract] [Full Text]
From Bedside to Bench: Does Mental and Physical Activity Promote Cognitive Vitality in Late Life? S. Studenski, M. C. Carlson, H. Fillit, W. T. Greenough, A. Kramer, G. W. Rebok.
Conference looks at the role of exercise for promoting mental health and delaying dementia.
[Abstract] [Full Text]
A Work in Progress: The Metabolic Syndrome J. A. Luchsinger.
Should we diagnose and treat the metabolic syndrome?
[Abstract] [Full Text]
Classic Paper: Mutation Selection and the Natural History of Cancer J. Cairns.
[Abstract] [PDF]
23 June 2006
Experimental Rodent Strains
Check out the biological characteristics of inbred and hybrid strains used to study aging.
[Strains]
Classic Papers
View historical (pre-1990) articles on aging-related topics.
[Classic Papers]
16 June 2006
Aging at the Interface of Stem Cell Renewal, Apoptosis, Senescence, and Cancer A. Nebel, E. Schaffitzel, M. Hertweck.
Scientists apply systems biology approaches to the field of aging-related research.
[Abstract] [Full Text]
Classic Paper: Pleiotropy, Natural Selection, and the Evolution of Senescence G. C. Williams.
The author discusses his theory of senescence.
[Abstract] [PDF]
9 June 2006
The Age of Cancer M. Leslie.
Cancer cells quiet gene behind premature aging disorder.
[Abstract] [Full Text]
Genetically Altered Mice: Werner Mice
Several strains designed to model a premature aging syndrome are described.
[Database]
2 June 2006
Pushing the Envelope M. Leslie.
Research blossoms on rare genetic disorders that might be linked to aging.
[Abstract] [Full Text]
Classic Paper: The Maintenance of the Accuracy of Protein Synthesis and Its Relevance to Aging L. E. Orgel.
The author discusses the "error catastrophe" hypothesis.
[Abstract] [PDF]
26 May 2006
Stem Cell Aging and Cancer
J. Fuller.
Do stem cells age? Cancer studies may bring us closer to an answer.
[Abstract] [Full Text]
The Age of Skin Cancers
A. Desai, R. Krathen, I. Orengo, E. E. Medrano.
Why are older men at greater risk for melanoma than older women?
[Abstract] [Full Text]
Shortcut to Death M. Leslie.
Stubby protein spurs cancer cells to eat themselves.
[Abstract] [Full Text]
19 May 2006
Toward a Better Understanding of Klotho Y. Nabeshima.
Analysis suggests a link between premature aging and calcium homeostasis.
[Abstract] [Full Text]
What Good Is Growing Old? M. Leslie.
Renegade researchers argue that aging is adaptive for the community.
[Abstract] [Full Text]
12 May 2006
Neuropathology in Alzheimer's Disease: Awaking from a Hundred-Year-Old Dream A. Nunomura, R. J. Castellani, H. Lee, P. I. Moreira, X. Zhu, G. Perry, M. A. Smith.
Are senile plaques and neurofibrillary tangles protective rather than pathogenic?
[Abstract] [Full Text]
Meetings and Events
The 10th International Conference on Alzheimer's Disease and Related Disorders will be held in Madrid in July.
[Calendar]
5 May 2006
A Shared Splice Site? M. Leslie.
Defect behind "premature aging" disorder might foster normal aging.
[Abstract] [Full Text]
Genes/Interventions Database: LMNA
Mutations that affect lamin A, a component of the nuclear lamina, cause Hutchinson-Gilford progeria syndrome.
[Database Entry]
28 April 2006
In Praise of Insulin Resistance M. Leslie.
Immune-cell metabolic defect might hinder atherosclerosis.
[Abstract] [Full Text]
Classic Paper: Effects of Food Restriction on Aging--Separation of Food Intake and Adiposity D. E. Harrison, J. Archer, C. M. Astle.
Genetically obese mice display extended longevity on a food-restricted diet.
[Abstract] [PDF]
21 April 2006
Aging in Check W. Dai and X. Wang.
Defects in two spindle checkpoint proteins lead to premature cell senescence and accelerated aging.
[Abstract] [Full Text]
Published Comments: Making Sense of SENS A. de Grey.
The author responds to criticisms in last week's Perspective on strategies for engineered negligible senescence.
[Comment]
14 April 2006
Environmental Movement M. Leslie.
Researchers are discovering how the molecules in cells' surroundings contribute to aging--and how tweaking them might rejuvenate tissues.
[Abstract] [Full Text]
Genes/Interventions Database: Plau
Overproduction of an extracellular protease in the brain is associated with life-span extension in mice.
[Database Entry]
7 April 2006
SENS and the Polarization of Aging-Related Research D. A. Gray and A. Bürkle.
Controversy surrounds the "strategies for engineered negligible senescence" concept and conference.
[Abstract] [Full Text]
Tag-Team Recycling M. Leslie.
Mechanisms for protein disposal interact.
[Abstract] [Full Text]
31 March 2006
Small-Fiber Neuropathy: Answering the Burning Questions E. Fink and A. L. Oaklander.
New techniques offer promise for diagnosing peripheral nerve disease.
[Abstract] [Full Text]
Teaching Resources Check out the figures, outlines, and other teaching materials suitable for courses on the science of aging.
[Resources]
24 March 2006
The Development of Amyloid β Protein Deposits in the Aged Brain D. R. Thal, E. Capetillo-Zarate, K. Del Tredici, H. Braak.
Different types of amyloid β protein deposits offer clues into the development of neurodegeneration.
[Abstract] [Full Text]
Aging in the Arts View a painting of moon goddess Chang E, who purportedly stole the elixir of immortality from her husband.
[Painting]
17 March 2006
Buffing Up the Family Jewels M. Beckman.
Obliterating a protein that fosters testosterone production keeps testicles young.
[Abstract] [Full Text]
Classic Paper: The Neuroendocrinology of Stress and Aging--The Glucocorticoid Cascade Hypothesis R. M. Sapolsky, L. C. Krey, B. S. McEwen.
Termination of adrenocortical stress hormone secretion is impaired in aged male rats.
[Abstract] [PDF]
10 March 2006
Craving an Answer M. Leslie.
After 70 years, researchers might be closing in on how calorie restriction extends life.
[Abstract] [Full Text]
Classic Paper: Action of Food Restriction in Delaying the Aging Process E. J. Masoro, B. P. Yu, H. A. Bertrand.
Decreased metabolic rate might not explain why food restriction slows aging.
[Abstract] [PDF]
3 March 2006
Genes/Interventions Database
Heat shock extends life span of yeast, worms, and flies.
[Database]
Meetings and Events
American Aging Association meeting in June will focus on interventions in aging and age-related diseases.
[Calendar]
24 February 2006
The Sour Side of Sweet M. Leslie.
Sugar derivatives take a toll on cells.
[Abstract] [Full Text]
Classic Paper: Detection of Inactive Enzyme Molecules in Ageing Organisms H. Gershon and D. Gershon.
Accumulation of nonfunctional proteins may play a key role in senescence.
[Abstract] [PDF]
17 February 2006
When Good Cdk5 Turns Bad Q. Guo.
Prolonged activation of the cyclin-dependent kinase-5 leads to neurodegeneration.
[Abstract] [Full Text]
Mucking With Metabolism M. Beckman.
Inability to repair DNA damage in mitochondria could foster metabolic syndrome.
[Abstract] [Full Text]
10 February 2006
Olfactory Loss in Aging N. E. Rawson.
Why does perception of volatile stimuli decline with age?
[Abstract] [Full Text]
3 February 2006
Meetings and Events
Learn about free radicals, innate immunity, cardiac regeneration, and more at this month's aging-related meetings.
[Calendar]
Web Links
Find links to databases, funding agencies, and labs conducting aging-related research.
[Web Links]
27 January 2006
Prion 2005--Between Fundamentals and Society's Needs C. Treiber.
Conference goes a step further in coordinating and reinforcing international research activities.
[Abstract] [Full Text]
The Way of the Honeybee M. Leslie.
Bees turn reproductive protein into antioxidant.
[Abstract] [Full Text]
20 January 2006
Dividing to Keep Muscle Together--The Role of Satellite Cells in Aging Skeletal Muscle R. T. Hepple.
Impaired satellite cell function might contribute to aging muscle atrophy.
[Abstract] [Full Text]
Double Duty M. Leslie.
Cholesterol-reducing receptor also curbs blood glucose.
[Abstract] [Full Text]
13 January 2006
Lessons from Drosophila Models of DJ-1 Deficiency D. J. Moore, V. L. Dawson, T. M. Dawson.
Fly models generally fail to exhibit key features of Parkinson's disease.
[Abstract] [Full Text]
Chain of Command M. Leslie.
Study fingers abettors of life-streching protein.
[Abstract] [Full Text]
6 January 2006
Biomarkers of Aging—Combinatorial or Systems Model? A. Kriete.
New bioinformatics search strategies might snare elusive biomarkers.
[Abstract] [Full Text]
Uncoupling Insulin M. Leslie.
SIRT1 boosts insulin release by blocking mitochondrial protein.
[Abstract] [Full Text]
23 December 2005
Harnessing Hormonal Signaling for Cardioprotection V. L. Ballard and J. M. Edelberg.
The jury is still out when it comes to a beneficial role for estrogen on the heart.
[Abstract] [Full Text]
Loose Chromosomes Sink Cells M. Leslie.
Gene-silencing mechanism falters in patients with premature aging disorder.
[Abstract] [Full Text]
16 December 2005
When T Cells Get Old G. Pawelec.
Is remediation possible for immunosenscence?
[Abstract] [Full Text]
Oxidants off the Hook? M. Leslie.
Fast-aging mice don't suffer oxidative overload.
[Abstract] [Full Text]
9 December 2005
Living Longer and Paying the Price? J. Q. Trojanowski, M. K. Jedrziewski, D. A. Asch.
Conference featured discussion of health care costs and longevity in America.
[Abstract] [Full Text]
Tapping Into Renewal M. Leslie.
Compound that boosts cell division slows Huntington's disease in mice.
[Abstract] [Full Text]
2 December 2005
T Cell Immunity and Aging S. D. Koch, J. Kempf, G. Pawelec.
Consortium reviews progress in understanding immunosenescence.
[Abstract] [Full Text]
Down with p53! M. Leslie.
Curtailing cancer-fighting protein's activity lengthens fly life.
[Abstract] [Full Text]
25 November 2005
Mitochondrial Dynamics in Cell Life and Death C. Scheckhuber.
Results discussed at a workshop on mitochondrial fusion and fission have relevance to apoptosis and aging.
[Abstract] [Full Text]
Shortchanged by Sir2 M. Leslie.
Longevity protein cuts off yeast survival.
[Abstract] [Full Text]
18 November 2005
Bionic Grandma R. J. Davenport.
Engineered tissues might someday rejuvenate the elderly.
[Abstract] [Full Text]
Immune Shaping and the Development of Alzheimer's Disease Vaccines H. J. Federoff and W. J. Bowers.
The search is on for efficacious AD vaccines that do not promote dangerous brain inflammation.
[Abstract] [Full Text]
A Switch in Time Saves Mind M. Leslie.
Aging rats preserve their memory by adjusting their response to stimulation.
[Abstract] [Full Text]
11 November 2005
Mitochondrial Genetics of Aging--Intergenomic Conflict Resolution D. M. Rand.
Understanding biochemical and genetic conflicts between mitochondria and nucleus sheds light on aging.
[Abstract] [Full Text]
Cancer Connection M. Leslie.
Tumor-fighter throttles life-extending protein SIRT1.
[Abstract] [Full Text]
4 November 2005
Developing a Research Agenda in Biogerontology: Basic Mechanisms H. R. Warner.
The author describes how research initiatives have been developed at the National Institute on Aging over the past two decades.
[Abstract] [Full Text]
Drug Bust M. Leslie.
Prescribing growth hormone to fight aging is illegal.
[Abstract] [Full Text]
28 October 2005
Neurochemical Insights C. Treiber.
Scientists aggregate in Austria to discuss neurodegenerative disease and brain function.
[Abstract] [Full Text]
Trapped Inside M. Leslie.
Pumping-protein failure might spur Alzheimer's disease.
[Abstract] [Full Text]
Caught With Their Proboscises in the Sugar Water M. Leslie.
Flies on life-extending diet eat more than expected.
[Abstract] [Full Text]
21 October 2005
What's Bugging You? M. Leslie.
Bacteria and viruses that attack us in our youths might return to cause some of the scourges of old age.
[Abstract] [Full Text]
Gone to Flab M. Leslie.
Overactive lipid-generating enzyme might spur muscles to pack in fat.
[Abstract] [Full Text]
14 October 2005
C. elegans Gives the Dirt on Aging M. Hertweck.
Presentations at the 15th International C. elegans Meeting provide new insights on aging.
[Abstract] [Full Text]
Fatal Hunger M. Leslie
Aging eggs might starve to death.
[Abstract] [Full Text]
7 October 2005
Revising the Standard Wisdom of C. elegans Natural History: Ecology of Longevity E. P. Caswell-Chen, J. Chen, E. E. Lewis, G. W. Douhan, S. A. Nadler and J. R. Carey.
A symbiotic relationship between C. elegans and snails provides a new context for understanding
the evolution of the worm and its life history traits.
[Abstract] [Full Text]
Turning Back the Clock R. J. Davenport.
Cancer drugs reverse nuclear defects of progeria.
[Abstract] [Full Text]
Cut the Fat M. Leslie.
Enzyme restores lipid-damaged DNA.
[Abstract] [Full Text]
30 September 2005
From Bedside to Bench: Research in Comorbidity and Aging G. D. Wieland.
Conference discusses the challenge of treating multiple overlapping health problems in the elderly.
[Abstract] [Full Text]
Appetite Suppressant M. Leslie.
Suicide-squelching molecule also slows cellular cannibalism.
[Abstract] [Full Text]
Battle of the Sexes R. J. Davenport.
Male bean weevils shape female aging.
[Abstract] [Full Text]
23 September 2005
Membrane Permeabilization: A Common Mechanism in Protein-Misfolding Diseases H. A. Lashuel.
If it looks like a pore and acts like a pore, is it a pathogenic pore?
[Abstract] [Full Text]
Plumbing Problem M. Leslie.
Lymph system malfunctions might promote obesity.
[Abstract] [Full Text]
Two Ways About It R. J. Davenport.
Phosphate-adding proteins send neurons down different roads to death after a stroke.
[Abstract] [Full Text]
16 September 2005
Good Timing R. J. Davenport.
Circadian clock teams with appetite-suppressing hormone to temper bone growth.
[Abstract] [Full Text]
Genes/Interventions Database
This database contains information about genes and interventions that have been studied with respect to their effects on life span or age-related neurological diseases.
[Database]
9 September 2005
Metals on the Brain C. Treiber.
Conference featured new results on metal-ion homeostasis and neurodegenerative disease.
[Abstract] [Full Text]
Get Out of the Way R. J. Davenport.
Parathyroid hormone builds more bone when a similar protein is absent.
[Abstract] [Full Text]
No Parkin Zone M. Leslie.
Researchers nab possible cell killer in Parkinson's disease.
[Abstract] [Full Text]
2 September 2005
Interfering with Longevity S. S. Lee.
RNA interference has transformed aging-related research in worms.
[Abstract] [Full Text]
Another Knock Against Cholesterol M. Leslie.
Artery clogger might promote Alzheimer's disease when damaged.
[Abstract] [Full Text]
Numb Together R. J. Davenport.
Protein relative of p53 has opposite influence on aging.
[Abstract] [Full Text]
26 August 2005
Brain Tumor-Associated Dementia J. McC. Noble, P. Canoll and L. S. Honig.
This study describes an unusual cause of cognitive decline.
[Abstract] [Full Text]
Tuning Up the Pancreas M. Leslie.
Mammalian version of yeast longevity protein boosts efficiency of insulin-making cells.
[Abstract] [Full Text]
Family Fued R. J. Davenport.
Protein relative of p53 has opposite influence on aging.
[Abstract] [Full Text]
19 August 2005
Making Young Tumors Old: A New Weapon Against Cancer? J. Sage.
Oncogene-induced senescence acts as a tumor suppressor mechanism.
[Abstract] [Full Text]
Beta Testing M. Leslie.
Lethargic pancreas gene might unleash diabetes.
[Abstract] [Full Text]
Hairy Breakup M. Beckman.
Alone, protein that replenishes chromosome ends finds capacity to fire up hair stem cells.
[Abstract] [Full Text]
12 August 2005
BRI-A
42 Transgenic Mice Q. Guo.
Mice that produce human Aβ1-42 in the absence of human amyloid precursor protein production develop amyloid-related pathologies.
[Abstract] [Full Text]
BRI-A40 Transgenic Mice Q. Guo.
Mice that produce human Aβ1-40 in the absence of human amyloid precursor protein production do not develop amyloid-related pathologies.
[Abstract] [Full Text]
Partly Cloudy R. J. Davenport.
Mice with Alzheimer's disease-linked gene variants suffer deteriorating retinas.
[Abstract] [Full Text]
Up to Speed M. Leslie.
Amphetamines spare mice from Parkinson's disease-like symptoms.
[Abstract] [Full Text]
5 August 2005
From Bedside to Bench: Research Agenda for Frailty L. P. Fried, E. C. Hadley, J. D. Walston, A. Newman, J. M. Guralnik, S. Studenski, T. B. Harris, W. B. Ershler and L. Ferrucci.
Conference aims for a better understanding of the physiology and etiology of this condition.
[Abstract] [Full Text]
Not a Chip off the Old Block M. Leslie.
Study identifies unexpected function for mammalian version of yeast longevity protein.
[Abstract] [Full Text]
Detour to Death R. J. Davenport.
Protein kills cells by diverting electrons and crafting free radicals.
[Abstract] [Full Text]
29 July 2005
How Long Do I Have, Doc? M. Leslie.
Protein foretells life span of genetically identical nematodes.
[Abstract] [Full Text]
Fat-Free Longevity R. J. Davenport.
Mutation spurs fat accumulation and longevity through separate paths.
[Abstract] [Full Text]
22 July 2005
Allelic Variation and Human Longevity A. Nebel and S. Schreiber.
Careful study design is key to the search for genetic differences that impact longevity.
[Abstract] [Full Text]
Error Prone R. J. Davenport.
Mitochondrial mutations might speed aging through rampant cell suicide.
[Abstract] [Full Text]
Bombshell M. Leslie.
Radioactive dating reveals cellular ages.
[Abstract] [Full Text]
15 July 2005
Aging Down Under S. J. Olshansky.
New organization promotes aging-related research in Australia.
[Abstract] [Full Text]
Pathological Partnership M. Leslie.
Study fingers p53 as an accomplice in Huntington's disease.
[Abstract] [Full Text]
Not Like the Other R. J. Davenport.
Older identical twins acquire different chromosome marks.
[Abstract] [Full Text]
8 July 2005
T-CIA: Investigating T Cells in Aging S. Koch, J. Kempf, G. Pawelec.
European program aims to understand immune dysregulation in the elderly.
[Abstract] [Full Text]
Hair Trigger R. J. Davenport.
Molecule induces skin cells to construct hair follicles.
[Abstract] [Full Text]
Odd SOD M. Leslie.
Out-of-shape proteins speed death in neuron-destroying disease.
[Abstract] [Full Text]
1 July 2005
Reactive Oxygen Species and Aging: Evolving Questions L. L. Dugan and K. L. Quick.
How do ROS contribute to aging in higher organisms?
[Abstract] [Full Text]
Metabolomics: Opening Another Window into Aging B. S. Kristal and Y. I. Shurubor.
What can analysis of the metabolome tell us about aging?
[Abstract] [Full Text]
Will We Find Biomarkers of Aging? R. J. Davenport.
Science's 125th anniversary special issue.
[Abstract] [Full Text]
How Can We Use Moderate Stresses to Fortify Humans and Slow Aging? M. Leslie.
Science's 125th anniversary special issue.
[Abstract] [Full Text]
How Can We Craft a Better Theory to Explain the Evolution of Aging? M. Leslie.
Science's 125th anniversary special issue.
[Abstract] [Full Text]
24 June 2005
Endothelial Progenitor Cell Therapy for Atherosclerosis: The Philosopher's Stone for an Aging Population? J. Kravchenko, P. J. Goldschmidt-Clermont, T. Powell, E. Stallard, I. Akushevich, M. S. Cuffe, K. G. Manton.
Effect of therapy on human life span is predicted to be comparable to that caused by eliminating cancer.
[Abstract] [Full Text]
Sticking It to Parkinson's Disease M. Leslie.
Vaccination spares mice from brain damage.
[Abstract] [Full Text]
Releasing the Pressure R. J. Davenport.
Eliminating kidney protein in mice relieves swelling spurred by diabetes drugs.
[Abstract] [Full Text]
17 June 2005
CB1 Knockout Mice M. Russell.
Cannabinoid receptors are involved in the control of bone mass and osteoclast activity.
[Full Text]
Before Their Time R. J. Davenport.
Eggs falter prematurely in mice without signaling molecule.
[Abstract] [Full Text]
Premature Emission M. Leslie.
Early surge in fat-fighting hormone might trigger obesity later in life.
[Abstract] [Full Text]
10 June 2005
The Longevity Gender Gap: Are Telomeres the Explanation? A. Aviv, J. Shay, K. Christensen, W. Wright.
Somatic cell selection might promote longevity in women.
[Abstract] [Full Text]
Why Females Live Longer Than Males: Control of Longevity by Sex Hormones J. Viña, C. Borrás, J. Gambini, J. Sastre, F. V. Pallardó.
Estrogens might prolong life by increasing expression of antioxidant enzymes.
[Abstract] [Full Text]
Mars and Venus R. J. Davenport.
Unearthing the reasons that age-related diseases afflict men and women differently might improve health care for both sexes.
[Abstract] [Full Text]
3 June 2005
Misdirection on the Road to Shangri-La S. J. Olshansky, B. A. Carnes, R. Hershow, D. Passaro, J. Layden, J. Brody, L. Hayflick, R. N. Butler, D. S. Ludwig.
The authors respond to a recent Perspective on a potential decrease in life expectancy.
[Abstract] [Full Text]
Ties That Bind the Brain R. J. Davenport.
Parkin and glutathione deficits slay dopamine-producing neurons in flies.
[Abstract] [Full Text]
New Trick for an Old Enzyme M. Leslie.
Famous as a chromosome capper, telomerase might also orchestrate general DNA repair.
[Abstract] [Full Text]
27 May 2005
Nitric Oxide and Oxidative Stress in Cardiovascular Aging S. V. Y. Raju, L. A. Barouch, J. M. Hare.
Researchers say NO thanks to oxidative stress.
[Abstract] [Full Text]
The Skeleton Goes to Pot R. J. Davenport.
Prodding marijuana receptors spurs bone loss.
[Abstract] [Full Text]
Hush, Little Gene M. Leslie.
Mystery molecule helps gene-quieting protein mothball DNA.
[Abstract] [Full Text]
20 May 2005
MiMage: A Pan-European Project on the Role of Mitochondria in Aging C. Scheckhuber and H. D. Osiewacz.
European researchers focus on mitochondria to pinpoint conserved mechanisms of aging.
[Abstract] [Full Text]
Spring Forward R. J. Davenport.
March babies hit menopause earliest.
[Abstract] [Full Text]
13 May 2005
Keep Time, Stay Healthy G. Block.
Is sleep-cycle disruption the reason altered circadian rhythm causes metabolic syndrome?
[Abstract] [Full Text]
Death in the Dirt M. Leslie.
Long-lived in the petri dish, mutant worms bite the dust in soil.
[Abstract] [Full Text]
Heart, Heal Thyself M. Leslie.
Researchers turn on possible heart-repair mechanism.
[Abstract] [Full Text]
6 May 2005
Carnosine: A Versatile Antioxidant and Antiglycating Agent V. P. Reddy, M. R. Garrett, G. Perry, M. A. Smith.
Will carnosine come of AGE as a therapeutic agent for diseases involving oxidative damage?
[Abstract] [Full Text]
Good as New M. Leslie.
Researchers uncover genetic instructions for remaking worm body.
[Abstract] [Full Text]
Oxygen Poisoning and X-irradiation: A Mechanism in Common R. Gerschman, D. L. Gilbert, S. W. Nye, P. Dwyer, and W. O. Fenn
[Abstract] [Full Text]
29 April 2005
The Art and Science of Anti-Aging Therapies J. Q. Trojanowski, M. K. Jedrziewski, B. Johnson, L. A. Whitaker.
Scientists discuss the convergence of theory and practice at a recent meeting.
[Abstract] [Full Text]
Shields Down M. Leslie.
Alzheimer's protein kills by tampering with cell's antioxidant defenses.
[Abstract] [Full Text]
Optimistic for Longevity R. J. Davenport.
High spirits reduce numbers of disease-linked molecules.
[Abstract] [Full Text]
22 April 2005
DJ-1–/– Mice J. Fuller.
Mouse model of Parkinson's disease suggests that DJ-1 protects neurons from oxidative stress.
[Full Text]
Harden My Heart R. J. Davenport.
Gene spurs blood vessels to amass calcium deposits.
[Abstract] [Full Text]
Sins of Synuclein M. Leslie.
Chemical attachments turn Parkinson's protein into cell killer.
[Abstract] [Full Text]
Defining the Diet R. J. Davenport.
Single ingredient might hold key to calorie restriction's benefits.
[Abstract] [Full Text]
15 April 2005
Time and Aging--Mechanisms and Meanings E. Wollscheid-Lengeling.
Whether we're killing ourselves by becoming too fat is a hefty question.
[Abstract] [Full Text]
Inflaming Chronic Pain M. Leslie.
Immune cells might trigger mysterious untreatable pain.
[Abstract] [Full Text]
8 April 2005
Future Mortality: A Bumpy Road to Shangri-La? S. Tuljapurkar.
Whether we're killing ourselves by becoming too fat is a hefty question.
[Abstract] [Full Text]
Dementia of the Alzheimer's Type and Accelerated Aging in Down Syndrome D. A. Devenny, J. Wegiel, N. Schupf, E. Jenkins, W. Zigman, S. J. Krinsky-McHale, and W. P. Silverman.
A case study.
[Abstract] [Full Text]
Power Cut M. Leslie.
Older mitochondria lose their oomph.
[Abstract] [Full Text]
Giant Steps R. J. Davenport.
Under tension, massive muscle protein relays signal to nucleus.
[Abstract] [Full Text]
1 April 2005
Feeling Spunky With JNK R. J. Davenport.
Protein funnels stress signals into insulin pathway and extends life.
[Abstract] [Full Text]
Mopping Up Nuclear Waste M. Leslie.
Molecule helps dispose of damaged proteins in the cell's command center.
[Abstract] [Full Text]
25 March 2005
Age-Related Neurodegenerative Changes and How They Affect the Gut P. R. Wade and P. J. Hornby.
Although the gut "loses its mind" with age, it remains relatively functional.
[Abstract] [Full Text]
b Blocker R. J. Davenport.
Diabetes-linked mutations cripple gene-control protein in pancreas cells.
[Abstract] [Full Text]
Hormone Give-and-Take M. Leslie.
Paucity of growth hormone doesn't buy extra time for rats.
[Full Text]
18 March 2005
The Genetic Basis of Aging: An Evolutionary Biologist's Perspective David N. Reznick.
Analyses of aging in model organisms offer a limited view of how senescence occurs.
[Abstract] [Full Text]
How Low Can You Go? R. J. Davenport.
Molecule might improve statins' cholesterol-depleting power.
[Abstract] [Full Text]
Outrunning Alzheimer's Disease M. Leslie.
Exercise curbs b amyloid buildup in mice.
[Abstract] [Full Text]
11 March 2005
Park2tm1Rpa Mice J. Fuller.
Mice designed to model a heritable form of Parkinson's disease do not exhibit parkinsonism.
[Full Text]
Sugar Rush M. Leslie.
Potential life-extending enzyme cranks up glucose synthesis.
[Abstract] [Full Text]
Early Warning R. J. Davenport.
Memory fades when b amyloid accumulates inside neurons.
[Abstract] [Full Text]
4 March 2005
Oxidative Mutagenesis, Mismatch Repair, and Aging A. M. Skinner and M. S. Turker.
Does oxidative stress both cause DNA damage and compromise mismatch repair?
[Abstract] [Full Text]
Will Humans Join the Club? R. J. Davenport.
Changes in insulin-signaling genes might extend human longevity.
[Abstract] [Full Text]
25 February 2005
Meeting Report: 4th European Congress of Biogerontology D. A. Gray and A. Bürkle.
Experts provided new insights into the fundamental mechanisms of aging.
[Abstract] [Full Text]
A New Biogerontology Lab in Newcastle D. A. Gray.
The University of Newcastle recently celebrated the opening of the Henry Wellcome Laboratory for Biogerontology Research.
[Abstract] [Full Text]
Stiff Competition R. J. Davenport.
Protein keeps joints from seizing up.
[Abstract] [Full Text]
The Two Faces of Leptin M. Leslie.
Fat-fighting hormone can strengthen, as well as weaken, the skeleton.
[Abstract] [Full Text]
18 February 2005
More Is Less: Neurogenesis and Age-Related Cognitive Decline in Long-Evans Rats J. L. Bizon and M. Gallagher.
Does neurogenesis help or hinder brain function?
[Abstract] [Full Text]
Now Hear This M. Leslie.
Gene therapy alleviates deafness in rodents.
[Abstract] [Full Text]
Short Circuit, Long Life R. J. Davenport.
Sloppy wiring in mitochondria extends fly longevity.
[Abstract] [Full Text]
11 February 2005
Drug Discovery in Neurodegenerative Diseases H. Geerts, J. Q. Trojanowski, V. M.-Y. Lee.
New research is meeting the need for drugs to counter neurodegeneration.
[Abstract] [Full Text]
Dosed to Death R. J. Davenport.
Thyroid hormone treatments shorten mouse life span.
[Abstract] [Full Text]
The Better to See You With M. Leslie.
Older folks surpass youngsters in discerning one kind of motion.
[Abstract] [Full Text]
7 February 2005
Lipofuscin and Aging: A Matter of Toxic Waste D. A. Gray, J. Woulfe.
Accumulation of this pigment might cause catastrophic lysosomal and proteasomal inhibition.
[Abstract] [Full Text]
Ageless No More M. Leslie.
Once thought immortal, gut bacteria suffer aging's toll.
[Abstract] [Full Text]
Plugged Up R. J. Davenport.
Broken pump abets calcium overload after a stroke.
[Abstract] [Full Text]
28 January 2005
Apoptotic Killing of Fibroblasts by Matrix-Bound Advanced Glycation Endproducts M. E. Obrenovich, V. M. Monnier.
AGE-modified extracellular matrix protein promotes programmed cell death.
[Abstract] [Full Text]
Coming Back for Seconds R. J. Davenport.
Extra doses of lipin protein spur obesity.
[Abstract] [Full Text]
Led Astray M. Leslie.
Worn-out cells prod healthy ones toward cancer.
[Abstract] [Full Text]
21 January 2005
Diabetes and Stem Cell Researchers Turn to the Lowly Spleen S. Kodama, M. Davis, D. L. Faustman.
Splenic stem cells might offer hope for the treatment of aging-related disease.
[Abstract] [Full Text]
Pay at the Pump R. J. Davenport.
Scans of failing hearts in patients reveal an energy crisis.
[Abstract] [Full Text]
14 January 2005
Zmpste24-/- Mice J. Fuller.
Reducing prelamin A abundance abolishes progeria-like phenotypes.
[Full Text]
Counting Down to Arthritis M. Leslie.
Extra repeated amino acid in a joint protein might promote cartilage breakdown.
[Abstract] [Full Text]
Worth Its Salt R. J. Davenport.
Elusive enzyme generates hormone that lowers blood pressure.
[Abstract] [Full Text]
7 January 2005
Report on the 14th Annual Meeting of the German Society for Geriatric Research C. Scheckhuber.
An eclectic view of German research on aging.
[Abstract] [Full Text]
Mix and Mismatch M. Leslie.
Cancer-promoting protein introduces mistakes in DNA pairing.
[Abstract] [Full Text]
New Age R. J. Davenport.
Novel method clocks yeast longevity.
[Abstract] [Full Text]
24 December 2004
Telomeres and Human Aging: Facts and Fibs A. Aviv.
The jury is still out on whether telomere dynamics is a surrogate for or a key determinant of human aging.
[Abstract] [Full Text]
Once More, With Feeling R. J. Davenport.
Hobbling glycation-detecting protein restores feeling in diabetic mice.
[Abstract] [Full Text]
Trashing Vision M. Leslie.
Cell receptor helps prevent garbage pileups in the eye.
[Abstract] [Full Text]
Natural Foods R. J. Davenport.
Wild-like pattern of feast and famine extends Medfly life span.
[Abstract] [Full Text]
Telltale Text M. Leslie.
Novelist's final work reveals early signs of Alzheimer's disease.
[Abstract] [Full Text]
17 December 2004
Gdf5-Cre/BmpR1afloxP Mice J. Fuller.
This strain serves as a model of osteoarthritis.
[Full Text]
Switching on Longevity M. Leslie.
Energy-measuring molecule might stretch life span.
[Abstract] [Full Text]
Ignorance Is Bliss M. Beckman.
Treatment makes cells from people with premature aging disorder overlook genetic abnormality and behave normally.
[Abstract] [Full Text]
Buddy System M. Beckman.
Young blood helps old muscle heal.
[Abstract] [Full Text]
Toxic Spill M. Beckman.
Parkin protects dopamine cargo within neurons from leaking.
[Abstract] [Full Text]
10 December 2004
Poly(ADP-Ribosyl)ation, PARP, and Aging S. Beneke and A. Bürkle.
PARP enzymes serve to protect the genome.
[Abstract] [Full Text]
Young at Brain M. Leslie.
Long-lived mice pump out extra neurons.
[Abstract] [Full Text]
3 December 2004
Mitochondrial Injury: A Hot Spot for Parkinsonism and Parkinson's Disease? B. I. Giasson.
Mutations in distinct genes might lead to Parkinson's disease through a common mechanism.
[Abstract] [Full Text]
Paying the Price R. J. Davenport.
Long-lived worms can't compete.
[Abstract] [Full Text]
Partners in Death M. Leslie.
Alzheimer's protein rouses cell-suicide enzyme.
[Abstract] [Full Text]
26 November 2004
Nuclear Hormone Receptors, Metabolism, and Aging: What Goes Around Comes Around K. Pardee, J. Reinking, and H. Krause.
Transcription factors link lipid metabolism and aging-related processes.
[Abstract] [Full Text]
Young at Heart R. J. Davenport.
Life-extending mutation preserves fly hearts.
[Abstract] [Full Text]
Pay by the Pound M. Leslie.
Added weight might take a toll on the brain.
[Abstract] [Full Text]
19 November 2004
F344BNF1 and BNF344F1 Hybrid Rats D. J. Holmes.
Hybrid strains are longer-lived and healthier than the parental strains.
[Abstract] [Full Text]
Culture Clash R. J. Davenport.
Yeast cells might sign suicide pact, but the idea remains controversial.
[Abstract] [Full Text]
Ironing Out Cell Death M. Leslie.
Metal-grabbing enzyme saves suicidal cells.
[Abstract] [Full Text]
Solving the Energy Crisis R. J. Davenport.
Signaling molecule spurs cells to generate mitochondria.
[Abstract] [Full Text]
12 November 2004
Proteomics in Aging-Related Research A. Gafni.
How many proteins does it take to age a cell?
[Abstract] [Full Text]
Out of Whack, Out of Mind M. Leslie.
Misaligned brain cells might sap memory as we age.
[Abstract] [Full Text]
5 November 2004
The Search for Biomarkers of Aging: Next Stop INK4a/ARF Locus G. P. Dimri.
Expression of two tumor suppressors increases markedly with age.
[Abstract] [Full Text]
Gut Instinct M. Leslie.
Intestinal microbes promote fat buildup in mice.
[Abstract] [Full Text]
Relay Man R. J. Davenport.
Molecule transmits estrogen's bone-saving signal through T cells.
[Abstract] [Full Text]
29 October 2004
Prey for Long Life R. J. Davenport.
The hunted don't necessarily age quickly.
[Abstract] [Full Text]
Stuck in the Skin M. Leslie.
Blood fats waylay immune cells.
[Abstract] [Full Text]
Amyloid Precursor Protein (APP) E693Q Transgenic Mice (APPDutch Mice) G. Zitnik.
This strain is a model for hereditary cerebral hemorrhage with amyloidosis.
[Full Text]
The Goldilocks Genes M. Leslie.
Having too many or too few copies of a gene might incite disease or accelerate aging.
[Abstract] [Full Text]
22 October 2004
Aging-Related Research in the "-omics" Age M. Kaeberlein.
Genome-wide analyses should provide insight into aging and longevity.
[Abstract] [Full Text]
Microarrays as a Tool to Investigate the Biology of Aging: A Retrospective and a Look to the Future S. Melov and A. Hubbard.
Microarray-based experiments present special problems and require careful design.
[Abstract] [Full Text]
Gone to Waste M. Leslie.
Inflammation-producing compound spurs muscle deterioration.
[Abstract] [Full Text]
Sticky Situation M. Beckman.
DNA landing sites for worm hibernation protein might flag aging-associated genes.
[Abstract] [Full Text]
Wilting Weed? R. J. Davenport.
Arabidopsis might provide new insights into the workings of protein linked to a premature aging disease.
[Abstract] [Full Text]
15 October 2004
Nuns and Monkeys: Investigating the Behavior of our Oldest Old J. A. Corr.
Studies of elderly people and nonhuman primates enhance each other.
[Abstract] [Full Text]
Homing In on a Hormone R. J. Davenport.
Telomerase aggravates oxidative damage in mitochondria.
[Abstract] [Full Text]
Wayward Sisters M. Beckman.
Progestin siblings exert opposite effects on monkey hearts.
[Abstract] [Full Text]
8 October 2004
Genes, Longevity and Technology: Meeting Report from the 2nd Conference on Functional Genomics of Aging in Crete R. Baumeister and M. Hertweck.
Scientists discuss aging from a systems viewpoint.
[Abstract] [Full Text]
Fanning the Flames R. J. Davenport.
Telomerase aggravates oxidative damage in mitochondria.
[Abstract] [Full Text]
1 October 2004
Ras: The Other Pro-Aging Pathway V. D. Longo.
Might Ras play a role in aging in mammals as well as in yeast?
[Abstract] [Full Text]
Knife Jugglers R. J. Davenport.
Painkillers shift Alzheimer's protein slicer.
[Abstract] [Full Text]
Off With Your (Fork)Head M. Leslie.
One stress-defusing pathway shuts down another.
[Abstract] [Full Text]
24 September 2004
Brown Norway Rat D. J. Holmes.
This strain is used extensively in studies involving autoimmune diseases.
[Abstract] [Full Text]
Acid Trip R. J. Davenport.
Blocking pH-sensitive calcium channels prevents stroke damage.
[Abstract] [Full Text]
Yin and Yang M. Leslie.
Inflammatory molecules fight and foster atherosclerosis.
[Abstract] [Full Text]
17 September 2004
A Century of Population Aging in Germany E. Hoffmann and S. Menning.
How old is Germany?
[Abstract] [Full Text]
Tarnished Vision R. J. Davenport.
Iron glut clouds eyes in mice.
[Abstract] [Full Text]
Fatal Distraction M. Beckman.
Disciplining misshapen proteins leaves cells vulnerable to oxidative stress and death.
[Abstract] [Full Text]
10 September 2004
TOR Pathway: Linking Nutrient Sensing to Life Span P. Kapahi and B. Zid.
Pathway provides clues to the mechanism of life-span extension by dietary restriction.
[Abstract] [Full Text]
Will a Filet a Day Keep the Neurologist Away? M. Leslie.
Fish oil molecule forestalls neuron damage in Alzheimer's mice.
[Abstract] [Full Text]
Leashing Leishmania R. J. Davenport.
Some old mice fight parasitic infection better than young mice do.
[Abstract] [Full Text]
3 September 2004
Aging of the Human Adrenal Cortex P. J. Hornsby.
Cell loss and compensatory overgrowth might cause age-related changes.
[Abstract] [Full Text] [PDF]
Not Wisely but Too Well: Aging as a Cost of Neuroendocrine Activity C. V. Mobbs.
Does neuroendocrine activity accelerate aging?
[Abstract] [Full Text]
Osteoarthritis N. Shakoor and R. F. Loeser.
A case study.
[Abstract] [Full Text]
Regnerating Regeneration R. J. Davenport.
Classic models illuminate possible ways to rejuvenate human tissues.
[Abstract] [Full Text] [PDF]
Déjà Vu I. Chen.
Arguments in the stem cell debate mirror the controversy surrounding the first test tube baby.
[Abstract] [Full Text] [PDF]
Stuck in the Craw M. Leslie.
Parkinson's proteins choke cell's recycling system.
[Abstract] [Full Text]
Hastening Death to Delay Aging R. J. Davenport.
New approach speeds hunt for manipulations that retard fly decrepitude.
[Abstract] [Full Text]
27 August 2004
Longevity Is Infectious R. J. Davenport.
Bacteria foster long life in young flies.
[Abstract] [Full Text]
Going the Extra Mile R. J. Davenport.
Molecular manipulations turn ordinary mice into athletic stars.
[Abstract] [Full Text]
20 August 2004
Rtel–/– Mice M. Russell.
The Rtel gene encodes a helicase-like protein that functions in the regulation of telomere length.
[Full Text]
Membranes of Death M. Leslie.
Molecule prevents suicide triggered by cell's protein factories.
[Abstract] [Full Text]
Hardy Helper R. J. Davenport.
Molecular partner urges worm protein to trigger survival pathway.
[Abstract] [Full Text]
13 August 2004
Ticking Fast or Ticking Slow, Through Shc Must You Go?
F. M. Martin and J. S. Friedman.
The adapter protein p66shc might integrate signals from several pathways to influence life span.
[Abstract] [Full Text]
Fast Burn M. Leslie.
Genetic modification that turns fat cells into furnaces extends longevity in mice.
[Abstract] [Full Text]
Eating Yourself to Life R. J. Davenport.
Signaling mechanisms that delay death induce starvation response in fruit flies.
[Abstract] [Full Text]
Trouncing Tau M. Beckman.
Mouse vaccine that neutralizes one Alzheimer's protein also eliminates another.
[Abstract] [Full Text]
6 August 2004
Murine Models of Life Span Extension J. K. Quarrie and K. T. Riabowol.
What can mice with defects in specific signaling molecules tell us about mammalian aging?
[Abstract] [Full Text]
Suppressed RAGE M. Leslie.
Cell-surface receptor battles compounds that promote aging by thwarting its alter ego.
[Abstract] [Full Text]
The Thing That Wouldn't Leave R. J. Davenport.
Immune cells that flock to fat-laden blood vessels stay when they should go.
[Abstract] [Full Text]
30 July 2004
Growing Pains R. J. Davenport.
As researchers sort through the hype surrounding growth hormone, they hope to uncover the molecule's actual benefits.
[Abstract] [Full Text]
Progressive Supranuclear Palsy M. Pourfar and J.-P. Vonsattel.
An uncommon disorder has many features similar to those of Parkinson's disease.
[Abstract] [Full Text]
High Anxiety M. Leslie.
Youthful stress impairs adult brain's ability to mint new cells.
[Abstract] [Full Text]
(Data)base Desires R. J. Davenport.
New resource compiles genes that potentially influence human aging.
[Abstract] [Full Text]
23 July 2004
Aging Cartilage and Osteoarthritis--What's the Link? R. F. Loeser Jr.
Low cell turnover, reduced growth factor signaling, and oxidative stress might contribute to this condition.
[Abstract] [Full Text]
Wising Up to Diabetes M. Leslie.
Insulin activity in brain and liver collaborate to prevent the metabolic disease.
[Abstract] [Full Text]
16 July 2004
Sex-Specific Effects of Interventions That Extend Fly Life Span J. M. S. Burger and D. E. L. Promislow.
Few studies measure the effects of manipulations on male versus female life span.
[Abstract] [Full Text]
Opposites Detract M. Leslie.
Hunger hormone quenches inflammation, opposing leptin.
[Abstract] [Full Text]
Long in the Tooth R. J. Davenport.
Paleolithic hominids outlived their predecessors, dental wear suggests.
[Abstract] [Full Text]
Resveratrol to the Rescue M. Leslie.
Compound that boosts yeast longevity also benefits worms and flies.
[Abstract] [Full Text]
9 July 2004
Immunotherapy for Alzheimer's Disease P. L. McGeer and E. McGeer.
Can a vaccine thwart this neurodegenerative disorder?
[Abstract] [Full Text]
All Pain, No Gain M. Leslie.
Shots in the elderly often miss their target, but researchers are starting to learn why.
[Abstract] [Full Text]
A Twist in an Early End R. J. Davenport.
Snafus in telomere unwinding foster a premature aging syndrome.
[Abstract] [Full Text]
Spiraling Toward Death M. Beckman.
Swirly mitochondria are associated with flies' demise.
[Abstract] [Full Text]
2 July 2004
Epigenetic Regulation of Aging in Honeybee Workers S. W. Omholt and G. V. Amdam.
Vitellogenin concentrations regulate life span in honeybees.
[Abstract] [Full Text]
Taking the Long View C. Aschwanden.
Studies that track people for decades have revealed tantalizing clues about the aging process that might otherwise lie undetected.
[Abstract] [Full Text]
Unraveling Socs M. Leslie.
Protein might block body's response to fat-reducing hormone.
[Abstract] [Full Text]
25 June 2004
S.W.A.T.-SOD Weapons and Tactics J. N. Sampayo and G. J. Lithgow.
Superoxide dismutase 1 is activated at the posttranslational level.
[Abstract] [Full Text]
Racing Against Time I. Chen.
Leslie Gordon was set for a career in pediatric ophthalmology until her son was diagnosed with a rare illness that mimics aspects of aging.
[Abstract] [Full Text]
Low-Cal Connections M. Beckman.
Calorie restriction might harness life-span extension protein to stop cell suicide.
[Abstract] [Full Text]
Stem Cell Savior M. Leslie.
Compound shelters neuron precursors during Parkinson's disease treatment.
[Abstract] [Full Text]
18 June 2004
Obesity Over the Life Course T. Mizuno, I-W. Shu, H. Makimura, C. Mobbs.
For the first time in modern history, the life expectancy of people in developed societies might begin to decrease.
[Abstract] [Full Text]
On Trial R. J. Davenport.
Jumping from laboratory to human studies puts researchers to the test.
[Abstract] [Full Text]
Too Much of a Good Thing R. J. Davenport.
Extra doses of antioxidant protein spur insulin resistance.
[Abstract] [Full Text]
11 June 2004
Inside Insulin Signaling, Communication Is Key to Long Life A. Antebi.
Activation of dFOXO in fat increases fly longevity.
[Abstract] [Full Text]
Neurodegeneration in Normal Brain Aging and Disease D. R. Thal, K. Del Tredici, H. Braak.
Activation of dFOXO in fat increases fly longevity.
[Abstract] [Full Text]
4 June 2004
Breaking in a New Function for Casein Kinase 2 J. C. Morales and P. B. Carpenter.
Enzyme plays a role in the repair of single-stranded DNA breaks.
[Abstract] [Full Text]
Counterattack E. Landhuis.
By squelching a fat-storage pathway, protein might connect diet with extended life.
[Abstract] [Full Text]
Peer Pressure R. J. Davenport.
Clustering sways antioxidant enzyme toward new behavior.
[Abstract] [Full Text]
28 May 2004
Declining Immunity with Age in the Wild D. Holmes and S. Austad.
Recent studies of wild bird populations provide evidence of immune senescence.
[Abstract] [Full Text]
GEHA--The Pan-European "Genetics of Healthy Aging" Project A. Nebel and S. Schreiber.
Consortium seeks to identify genes that promote long life and good health.
[Abstract] [Full Text]
A Life of Fusion I. Chen.
Olivia Pereira-Smith came from India, learned American science, and forged a lifelong research partnership studying cell aging.
[Abstract] [Full Text]
Symphony of Errors E. Landhuis.
Sloppy proofreading of mitochondrial DNA spurs a premature demise.
[Abstract] [Full Text]
Merging Routes R. J. Davenport.
Multiple paths lead to senescence.
[Abstract] [Full Text]
21 May 2004
Early Life Predictors of Old-Age Life Expectancy B. A. Rikke.
Combined measures of T cell subsets, body weight, and hormone concentrations in young mice predict life span.
[Abstract] [Full Text]
Shining a Light on Long Life M. Leslie.
Scientists identify key step in fruit fly longevity pathway.
[Abstract] [Full Text]
Anxious Aging M. Beckman.
Oxidatively stressed and old flies turn on many similar genes.
[Abstract] [Full Text]
14 May 2004
Vital Connections S. D. Pletcher.
Network analyses yield insights into the genetic mechanisms of aging.
[Abstract] [Full Text]
The Ageless Question--What Accounts for Age-Related Cognitive Decline? A. Nagahara and M. H. Tuszynski.
New results implicate a specific region of the hippocampus.
[Abstract] [Full Text]
Learning Is in the Blood M. Leslie.
Weakening the immune system saps brainpower.
[Abstract] [Full Text]
Calorie Restriction Un-SIR-tainty R. J. Davenport.
Yeast don't need SIR2 to starve their way to long life.
[Abstract] [Full Text]
Slipshod Survival M. Beckman.
Mice that produce energy inefficiently live longer than those that don't.
[Abstract] [Full Text]
7 May 2004
Come One, Come All S. S. Lee.
Gene expression profiles of individual aging nematodes differ from those of a synchronized worm population.
[Abstract] [Full Text]
Slacking Off E. Landhuis.
DNA-break repair pathway poops out in older cells.
[Abstract] [Full Text]
If Telomeres Thrive, You Will Survive M. Leslie.
Augmenting chromosome caps extends worm life span.
[Abstract] [Full Text]
30 April 2004
Methods for Genetic Dissection of Complex Traits T. F. C. Mackay.
The author responds to a recent SAGE KE Perspective on quantitative trait loci mapping studies.
[Abstract] [Full Text]
Many Roads to Ruin M. Leslie.
Aging undermines different tissues and organs in different ways. Understanding how might help us stay healthy longer.
[Abstract] [Full Text]
From Womb the Bell Tolls R. J. Davenport.
Stressing a fetus creates health problems that persist into old age.
[Abstract] [Full Text]
Bad to the Bone M. Leslie.
Proteins that build skeletons in embryos promote bone loss in the aged.
[Abstract] [Full Text]
23 April 2004
Physiological Complexity, Aging, and the Path to Frailty L. A. Lipsitz.
The fractal nature of physiological processes declines with age.
[Abstract] [Full Text]
Lethal Leak R. J. Davenport.
Protein that shortens mouse life span opens holes in mitochondria.
[Abstract] [Full Text]
Illegal Formation M. Leslie.
Stubby telomeres upset chromosome pairing in sperm and eggs.
[Abstract] [Full Text]
16 April 2004
A New Way to Lose Your Nerve A. I. Basbaum.
Bilateral loss of innervation can occur after unilateral nerve injury.
[Abstract] [Full Text]
Lightheaded M. Leslie.
Fat-produced hormone infiltrates the brain to slash weight.
[Abstract] [Full Text]
Fork in the Road R. J. Davenport.
Separate branches in insulin-related signaling pathway control worm hibernation and life span.
[Abstract] [Full Text]
Puzzling Out the Pieces E. Landhuis.
Dieting and dwarfism work together and separately at the molecular level to boost longevity.
[Abstract] [Full Text]
9 April 2004
Does Sex Age You? S. R. Proulx.
The dynamics of sexual encounters put a lower limit on life span.
[Abstract] [Full Text]
Hidden Talents M. Leslie.
Proteins implicated in Alzheimer's disease also coddle brain cells.
[Abstract] [Full Text]
More Without TOR M. Beckman.
Inhibiting nutrient sensor extends life span in fruit flies.
[Abstract] [Full Text]
Composed by Leptin M. Beckman.
Early in life, appetite hormone sets up circuitry that controls food intake during adulthood.
[Abstract] [Full Text]
Ercc1-/- Mice (Ercc1tm1Dwm Mice) J. Fuller.
ERCC1 functions in nucleotide excision repair and recombination repair.
[Full Text]
PARP-/- Mice J. Fuller.
PARP is an ADP-ribosyltransferase that functions in the posttranslational modification of nuclear proteins.
[Full Text]
2 April 2004
Werner Syndrome Protein--Unwinding Function to Explain Disease R. J. Monnat Jr. and Y. Saintigny.
Role in homologous recombination might be key to understanding cell defects.
[Abstract] [Full Text]
Wind at His Back I. Chen.
Trey Powers has been sailing at full speed into gerontology research since the age of 14.
[Abstract] [Full Text]
Never Too Old? M. Leslie.
Calorie-slashing diet might lengthen lives of even graying animals.
[Abstract] [Full Text]
26 March 2004
How Good Are Quantitative Complementation Tests? P. M. Service.
The search for life-span genes in Drosophila.
[Abstract] [Full Text]
The Flavor of Aging R. J. Davenport.
As researchers decipher why the ability to smell and taste deteriorates in the elderly, they hope to uncover ways to make aging more palatable.
[Abstract] [Full Text]
The Little RNAs That Could M. Leslie.
Midget RNA molecules trigger neuron maturation through unexpect
